02) and 3 in those with hyperleukocytosis (??50,000/μl) (p?=?0.002). CONCLUSION MGA allowed tailored post-consolidation in 53.8% of patients after high-dose aracytin induction, with long-term survival doubling that reported in the literature after standard-dose cytarabine regimens. TRIAL REGISTRATION The study was registered with the Umin Clinical Trial Registry (www.umin.ac.jp/ctr), number R000014052.PURPOSE To evaluate short and long-term effects of a multifactorial and multidisciplinary in-patient municipality intervention including training of activities of daily living, cardiovascular exercise, resistance training and social activities on quality-of-life, need-of-care, and physical function in older adults at risk of further functional decline. METHOD A cohort study including data collected rigorously during 3.5&nbsp;years at an in-patient municipality rehabilitation center in Aalborg, Denmark. Patients received a multifactorial and multidisciplinary intervention. Outcomes were quality-of-life (EQ5D), weekly need-of-care hours, and test of physical functioning (sit-to-stand, 6-min walking test, tandem balance). RESULTS Data was collected from 532 patients (63.3% women). The median [5; 95 percentiles] age was 79 [55; 92] years with a length-of-stay of 21 [8; 55] days. The mean (95% CI) EQ5D index score showed a clinically relevant improvement from admission 0.46 (0.44; 0.48) to discharge 0.69 (0.67; 0.71) and there was no decline 6-month postdischarge 0.67 (0.64; 0.70). The weekly need-of-care decreased significantly by 7.2 (6.6, 7.9) h from a mean of 9.8&nbsp;h before admission to 2.6&nbsp;h 6-month postdischarge. Sit-to-stand improved from 6.3 (6.0; 6.7) to 9.3 (8.9; 9.6) repetitions, 6-min walking test from 147 (138; 156) to 217 (207; 227) m, and tandem balance from 20.7 (19.8; 21.6) to 25.2 (24.8; 26.2) s. CONCLUSION Our results were remarkable and highlight that a well-structured multifactorial and interdisciplinary intervention with a clear aim and inclusion criteria related to functional decline may lead to long-term clinically relevant improvements in functionally declining older adults. Future studies should, however, explore similar interventions in comparable populations preferably in randomized controlled designs.PURPOSE Poor oral conditions in older adults are not limited to oral problems, which lead to physical problems. Prior research insufficiently has probed the relationship between oral health and physical function. This study investigated the relationship between oral health status and grip strength in older adults living in the community. METHODS This study used data from the 2014-2018 Korean National Health and Nutrition Survey. Oral health status was assessed by the type of dental prosthesis, the number of teeth. Grip strength was determined as the highest value among the three consecutive measurements of the dominant hand. The covariates included age, income, education, alcohol drinking, smoking, body mass index, sedentary time, comorbidity and number of caries teeth. Multiple logistic regression analysis was performed to examine the association between oral health status and grip strength. RESULTS Data on 6,437 older adults (men 2766; women 3671) were analyzed. The mean age was 72.9?±?0.1&nbsp;years. In the crude model of logistic regression analysis, both men and women had an association between full denture use and low grip strength compared to high grip strength. After controlling for covariates, the remaining 0-9 teeth was associated with low grip strength compared to high grip strength in men [odds ratio (OR)?=?1.39, 95% confidence interval (CI)?=?1.03-1.88]. The use of full dentures was also associated with low grip strength compared to high grip strength in men (OR?=?1.47, 95% CI?=?1.09-1.98). No significant associations were found in women. CONCLUSION Low handgrip strength was associated with using full dentures and remaining 0-9 teeth in older men. Low grip strength, one of the key characteristics of sarcopenia and frailty, may serve as an important indicator of poor oral health, especially among men in late life.PURPOSE Today, with an increasingly older population, it is essential to have well-educated and well-prepared nurses who can meet the health-related needs of geriatric patients but in some cases students have difficulty in understanding and empathizing with older persons. The impact of use of an aged simulation suit on the empathy and attitudes of nursing students towards older persons was investigated in this study. METHODS A descriptive mixed-methods study was conducted, using the Basic Empathy Scale, The Kogan's Attitude towards Old People Scale, and semi-structured interviews. RESULTS The Kogan's Attitude towards Old People Scale mean scores and the Basic Empathy Scale mean scores showed that there was a statistically significant increase in the empathy and attitude scores of students from the high-score group after they had carried out tasks using an aged simulation suit. A total of four themes were determined through data analysis. CONCLUSION The use of an aged simulation suit proved to be an effective educational technique which made a positive contribution towards nursing students' development of empathy and also made a positive change in their attitude towards older persons.PURPOSE Hip fractures are associated with considerable morbidity, excess mortality, and significant healthcare expenditure. There are approximately 3700 hip fractures in Ireland per annum and this figure is set to rise in the next decade in parallel with the ageing population. Approximately 5% of patients who sustain a hip fracture will die in hospital, with less than half of survivors regaining their pre-operative level of function. The authors aimed to identify the determinants of in-hospital mortality post-hip fracture in Ireland 2013-2017. METHODS A secondary analysis of 15,603 patients in the Irish Hip Fracture Database (IHFD) was conducted. Both descriptive and analytical statistics were produced. Univariate and multivariate logistic regression was carried out. https://www.selleckchem.com/products/jw74.html RESULTS 31% (n?=?4796) of patients were male and 69% (n?=?10,807) were female. Mean age for males was 75&nbsp;years (SD 13.5) and 79&nbsp;years for females (SD 10.5). Median in-hospital mortality was 4.7% (n?=?711) (range 2.7-6.2). Univariate logistic regression revealed 11 statistically significant predictors of in-hospital mortality; however, only four remained statistically significant on multivariate analysis [not mobilised day of/after surgery (OR 1.